UK-CAB 71: Broadly Neutralising Antibodies (bNABs), POPPY Sleep study feedback

Friday 24 January 2020

Programme

09.15-09.25 Arrival, tea and refreshments
09:30-10:00 Welcome and introductions
UK-CAB updates
Company pre-meeting
10:00-11:30 Company meeting: ViiV Healthcare
11.30-11.40 Break
11.40-12.40 bNAbs – Simon Collins, HIV i-Base
12.45-14.00 Lunch
14.00-16.00 POPPY Sleep study community feedback – Alan Winston and Caroline Sabin
16.00-16:10 Break
16:10 -16.40 Conferences feedback – BHIVA, EACS
16.40-17.00 Members Updates
Meeting reflection
Any other business & reflection
17.00 Meeting close

Slides and meeting report

To be uploaded after the meeting.

Background reading

The Rise of Broadly Neutralizing Antibodies
https://www.avac.org/blog/rise-broadly-neutralizing-antibodies

bNAbs for HIV prevention: extended-release VRC01, AMP study, 10E8 safety signal and pan-clade challenges
http://i-base.info/htb/35260

Gilead announces licensing agreement for Rockefeller University bNAbs
http://i-base.info/htb/37084

POPPY Sleep Sub study
https://www.ucl.ac.uk/global-health/research/a-z/POPPY-sleep-sub-study

Research summary:
Very little is known about the effects, if any, being HIV positive and being on anti-HIV medication may have on sleeping and sleep patterns. The aims of this study are to see if sleep is affected by being HIV positive, and if any changes to sleep then affect other functions in the body such as brain function.

It is a sub-study of the POPPY (Pharmacokinetic and Clinical Observations in People Over Fifty) study and the aim is for 500 main study participants to join this sub-study. It is an observational study (does not require participants to take any specific medication) taking place at 7 hospitals in the UK and Ireland. It is anticipated it will take around 2 years to complete the visits on 500 participants. This sub-study is being funded by the National Institutes of Health in the USA.

The research involved a study visit at the clinic which is expected to take up to 2 hours. At this visit participants will undergo brain function (cognitive) tests, complete a study questionnaire, give a brief medical history regarding their sleep and have some clinical measurements taken. Participants will then be given 2 devices and a sleep diary to complete over 7 days.

The first device is an Actigraph which records physical activity and sleep/wake patterns and will be worn for 7 consecutive days and nights. The second device, which will be worn for only one of those nights, is a pulse oximeter which records the levels of oxygen in the blood. The participants will return the devices and diaries to clinic at the end of the 7 days and have a fasting blood sample taken.

HIV is not associated with sleep-disordered breathing – poster at BHIVA conference
https://www.bhiva.org/file/5ca73250cc0a7/P063.pdf

Financial support

The UK-CAB receives unrestricted funding from some pharmaceutical companies towards the direct costs of holding four meetings each year.

This funding supports the travel and accommodation costs for members to attend from outside London, plus the cost of catering. The content, programme and agenda for meetings is decided by the UK-CAB steering group in consultation with the wider membership. Funding is unconnected to meeting content.

Companies that develop and market medicines have a responsibility to actively engage with advocacy organisations. HIV positive people and their advocates should also be able to ask manufacturers directly about the safety and efficacy of their products. We should be involved in their proposals for future research.

For a list of companies that support the UK-CAB please see the “about us” page.

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