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Head-to-head randomized trials mostly industry sponsored & favour the sponsor

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Paul Clift
Member
Posts: 467
Head-to-head randomized trials mostly industry sponsored & favour the sponsor
Posted on: March 12 2015, 01:48 pm

You might be interested in reading this paper - it's on open access - by M.E. Flacco et al: Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor.

Conclusion
The literature of head-to-head RCTs is dominated by the industry. Industry-sponsored comparative assessments systematically yield favorable results for the sponsors, even more so when noninferiority designs are involved.

Read online or download a pdf here http://www.jclinepi.com/article/S0895-4356(15)00058-X/abstract?cc=y

Best wishes
Paul
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Ben Cromarty
Member
Posts: 451
Re: Head-to-head randomized trials mostly industry sponsored & favour the sponsor
Reply #1 on: March 12 2015, 02:33 pm

Hi, paul...

...interesting article - but hardly a surprise!

John P.A. Ioannidis is a Professor of Health Research and Policy at Stanford School of Medicine. He is best known for his research and published papers on scientific studies, particularly the 2005 paper "Why Most Published Research Findings Are False". He reports n the many types of bias that skew results. This is a seminal paper, albeit quite complex in parts (lots of complex statistics).

One key reason for this recent finding is that there is considerable skewing to publishing only those papers that have a positive result. So, if the RCT sets out to prove something (like non-inferiority of drug A vs drug B), if the results do not show this, it won't get published...so all the published results tend then to favour the sponsor.
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Paul Clift
Member
Posts: 467
Re: Head-to-head randomized trials mostly industry sponsored & favour the sponsor
Reply #2 on: March 12 2015, 02:40 pm

Thanks Ben!
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