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Impact of co-morbidity and aging on health

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Impact of co-morbidity and aging on health
Posted on: April 26 2017, 10:45 am

Dear CAB Members,

I saw this article on PubMed (Impact of co-morbidity and aging on health-related quality of life in HIV-positive and HIV-negative individuals.) and thought it might be of interest.

I am not sure what the extricate is for this type of posting so I have just cut and pasted as much of the article below.

Kind Regards,

Paul.

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Item 1 of 1    (Display the citation in PubMed)

1.   AIDS. 2017 Apr 19. doi: 10.1097/QAD.0000000000001511. [Epub ahead of print]
Impact of co-morbidity and aging on health-related quality of life in HIV-positive and HIV-negative individuals.

Langebeek N1, Kooij KW, Wit FW, Stolte IG, Sprangers MAG, Reiss P, Nieuwkerk PT; AGEhIV Cohort Study Group.
Author information:

1
aDepartment of Internal Medicine and Infectious Diseases, Rijnstate Hospital Arnhem, The Netherlands bDepartment of Medical Psychology, Academic Medical Centre, Amsterdam, The Netherlands cDepartment of Global Health, Academic Medical Centre and Amsterdam Institute for Global Health and Development, The Netherlands dDivision of Infectious Diseases and Centre for Infection and Immunity Amsterdam (CINIMA), The Netherlands eDepartment of Infectious Diseases, Public Health Service of Amsterdam, The Netherlands fHIV Monitoring Foundation, Amsterdam, The Netherlands.
Abstract

BACKGROUND:

HIV-infected individuals may be at risk for the premature onset of age-associated non-communicable co-morbidities. Being HIV-positive, having comorbidities and being of higher age may adversely impact health-related quality of life (HRQL). We investigated the possible contribution of HIV infection, co-morbidities, and age on HRQL and depression.

METHODS:

HIV-infected individuals and uninfected controls from the AGEhIV Cohort Study were screened for the presence of co-morbidities. They completed the Short Form 36-item Health Survey to assess HRQL and the nine-item Patient Health Questionnaire to assess depression. Linear and logistic regression were used to investigate to which extent co-morbidities, aging and HIV infection were independently associated with HRQL and depression.

RESULTS:

HIV-infected individuals (n = 541) reported significantly worse physical and mental HRQL and had a higher prevalence of depression than HIV-uninfected individuals (n = 526). A higher number of co-morbidities and HIV-positive status were each independently associated with worse physical HRQL, whereas HIV-positive status and younger age were independently associated with worse mental HRQL and more depression. The difference in physical HRQL between HIV-positive and HIV-negative individuals did not become greater with a higher number of co-morbidities or with higher age.

CONCLUSIONS:

In a cohort of largely well-suppressed HIV-positive participants and HIV-negative controls, HIV-positive status was significantly and independently associated with worse physical and mental HRQL and with an increased likelihood of depression. Our finding that a higher number of co-morbidities was independently associated with worse physical HRQL reinforces the importance to optimize prevention and management of co-morbidities as the HIV-infected population continues to age.

PMID: 28426532

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Ben Cromarty
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Posts: 451
Re: Impact of co-morbidity and aging on health
Reply #1 on: April 26 2017, 02:04 pm

Hi, Paul...

...thanks for this. It confirms what I think we already know from other studies. Dr Fiona Lampe gave a good paper at BHIVA on a very similar topic, looking at a bigger group of people in the UK - ASTRA and AURAH studies. Because it was a much bigger study (with over 3000 people in each), she was able to look at the impact of a range of factors influencing mental health on PLWH in the UK. Her presentation is on the BHIVA website:

http://www.bhiva.org/Presentations170407.aspx

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